{"best_oa_location":{"endpoint_id":null,"evidence":"deprecated","host_type":"publisher","is_best":true,"license":"cc-by","oa_date":"2020-04-06","pmh_id":null,"repository_institution":null,"updated":"deprecated","url":"https://doi.org/10.7554/elife.55143.sa2","url_for_landing_page":"https://doi.org/10.7554/elife.55143.sa2","url_for_pdf":null,"version":"publishedVersion"},"data_standard":2,"doi":"10.7554/elife.55143.sa2","doi_url":"https://doi.org/10.7554/elife.55143.sa2","first_oa_location":{"endpoint_id":null,"evidence":"deprecated","host_type":"publisher","is_best":true,"license":"cc-by","oa_date":"2020-04-06","pmh_id":null,"repository_institution":null,"updated":"deprecated","url":"https://doi.org/10.7554/elife.55143.sa2","url_for_landing_page":"https://doi.org/10.7554/elife.55143.sa2","url_for_pdf":null,"version":"publishedVersion"},"genre":"peer-review","has_repository_copy":false,"is_oa":true,"is_paratext":false,"journal_is_in_doaj":true,"journal_is_oa":true,"journal_issn_l":"2050-084X","journal_issns":"2050-084X","journal_name":"eLife","oa_locations":[{"endpoint_id":null,"evidence":"deprecated","host_type":"publisher","is_best":true,"license":"cc-by","oa_date":"2020-04-06","pmh_id":null,"repository_institution":null,"updated":"deprecated","url":"https://doi.org/10.7554/elife.55143.sa2","url_for_landing_page":"https://doi.org/10.7554/elife.55143.sa2","url_for_pdf":null,"version":"publishedVersion"}],"oa_locations_embargoed":[],"oa_status":"gold","published_date":"2020-04-06","publisher":"eLife Sciences Publications, Ltd","title":"Author response: CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks","updated":"2026-10-28T10:57:32Z","year":2020,"z_authors":[{"author_position":"first","is_corresponding":false,"raw_affiliation_strings":["Department of Molecular and Cell Biology, University of California, Berkeley"],"raw_author_name":"Joshua C Cofsky"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["California Institute for Quantitative Biosciences (QB3), University of California, Berkeley","Department of Molecular and Cell Biology, University of California, Berkeley","Howard Hughes Medical Institute, University of California, Berkeley"],"raw_author_name":"Deepti Karandur"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Department of Molecular and Cell Biology, University of California, Berkeley"],"raw_author_name":"Carolyn J Huang"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Department of Molecular and Cell Biology, University of California, Berkeley"],"raw_author_name":"Isaac P Witte"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["California Institute for Quantitative Biosciences (QB3), University of California, Berkeley","Department of Chemistry, University of California, Berkeley","Department of Molecular and Cell Biology, University of California, Berkeley","Howard Hughes Medical Institute, University of California, Berkeley","MBIB Division, Lawrence Berkeley National Laboratory"],"raw_author_name":"John Kuriyan"},{"author_position":"last","is_corresponding":false,"raw_affiliation_strings":["California Institute for Quantitative Biosciences (QB3), University of California, Berkeley","Department of Chemistry, University of California, Berkeley","Department of Molecular and Cell Biology, University of California, Berkeley","Howard Hughes Medical Institute, University of California, Berkeley","MBIB Division, Lawrence Berkeley National Laboratory"],"raw_author_name":"Jennifer A Doudna"}]}