{"best_oa_location":{"endpoint_id":"2460c9cd9694d552451","evidence":"deprecated","host_type":"repository","is_best":true,"license":"cc-by","oa_date":"2026-05-25","pmh_id":"oai:pure.ed.ac.uk:openaire/4b6400b6-f99c-4a8b-8633-0ff6db15e901","repository_institution":"University of Edinburgh","updated":"deprecated","url":"https://www.research.ed.ac.uk/en/publications/4b6400b6-f99c-4a8b-8633-0ff6db15e901","url_for_landing_page":"https://www.research.ed.ac.uk/en/publications/4b6400b6-f99c-4a8b-8633-0ff6db15e901","url_for_pdf":null,"version":"publishedVersion"},"data_standard":2,"doi":"10.1056/nejmoa2601283","doi_url":"https://doi.org/10.1056/nejmoa2601283","first_oa_location":{"endpoint_id":"2460c9cd9694d552451","evidence":"deprecated","host_type":"repository","is_best":true,"license":"cc-by","oa_date":"2026-05-25","pmh_id":"oai:pure.ed.ac.uk:openaire/4b6400b6-f99c-4a8b-8633-0ff6db15e901","repository_institution":"University of Edinburgh","updated":"deprecated","url":"https://www.research.ed.ac.uk/en/publications/4b6400b6-f99c-4a8b-8633-0ff6db15e901","url_for_landing_page":"https://www.research.ed.ac.uk/en/publications/4b6400b6-f99c-4a8b-8633-0ff6db15e901","url_for_pdf":null,"version":"publishedVersion"},"genre":"journal-article","has_repository_copy":true,"is_oa":true,"is_paratext":false,"journal_is_in_doaj":false,"journal_is_oa":false,"journal_issn_l":"0028-4793","journal_issns":"0028-4793,0096-6762,1533-4406,2331-4710","journal_name":"New England Journal of Medicine","oa_locations":[{"endpoint_id":"2460c9cd9694d552451","evidence":"deprecated","host_type":"repository","is_best":true,"license":"cc-by","oa_date":"2026-05-25","pmh_id":"oai:pure.ed.ac.uk:openaire/4b6400b6-f99c-4a8b-8633-0ff6db15e901","repository_institution":"University of Edinburgh","updated":"deprecated","url":"https://www.research.ed.ac.uk/en/publications/4b6400b6-f99c-4a8b-8633-0ff6db15e901","url_for_landing_page":"https://www.research.ed.ac.uk/en/publications/4b6400b6-f99c-4a8b-8633-0ff6db15e901","url_for_pdf":null,"version":"publishedVersion"}],"oa_locations_embargoed":[],"oa_status":"green","published_date":"2026-05-25","publisher":"Massachusetts Medical Society","title":"In Vivo Base Editing of\n                    <i>PCSK9</i>\n                    with VERVE-102 for Hypercholesterolemia","updated":"2026-08-01T13:25:39Z","year":2026,"z_authors":[{"author_position":"first","is_corresponding":false,"raw_affiliation_strings":["Verve Therapeutics, a wholly owned subsidiary of Eli Lilly, Boston"],"raw_author_name":"Scott B. Vafai"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Richmond Pharmacology, London","St. George\u2019s University of London, London"],"raw_author_name":"J\u00f6rg T\u00e4ubel"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Richmond Pharmacology, London"],"raw_author_name":"Thomas Ashdown"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Barts Health NHS Trust, London","Institute of Cardiovascular Science, University College London, London"],"raw_author_name":"Riyaz S. Patel"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Barts Health NHS Trust, London"],"raw_author_name":"Sadaf Diamondali"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Imperial College London, London"],"raw_author_name":"Jaimini Cegla"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["National Institute for Health and Care Research\u2013Wellcome Trust Clinical Research Facility, Manchester University NHS Foundation Trust, Manchester, United Kingdom"],"raw_author_name":"Handrean Soran"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["National Institute for Health and Care Research\u2013Wellcome Trust Clinical Research Facility, Manchester University NHS Foundation Trust, Manchester, United Kingdom"],"raw_author_name":"Bilal Bashir"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Centricity Research, Toronto","LMC Diabetes and Endocrinology, Toronto"],"raw_author_name":"Alexander Abitbol"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Department of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal","ECOGENE-21 Clinical Research Center, Chicoutimi, QC, Canada"],"raw_author_name":"Daniel Gaudet"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Department of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal","ECOGENE-21 Clinical Research Center, Chicoutimi, QC, Canada"],"raw_author_name":"Alex Lauzi\u00e8re"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Department of Medicine, University of British Columbia, Vancouver, Canada","Healthy Heart Program Prevention Clinic, St. Paul\u2019s Hospital, Vancouver, BC, Canada"],"raw_author_name":"Liam R. Brunham"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["British Heart Foundation Centre for Research Excellence, University of Edinburgh, Edinburgh"],"raw_author_name":"David E. Newby"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Victorian Heart Institute, Monash University, Melbourne, VIC, Australia"],"raw_author_name":"Stephen J. Nicholls"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["New Zealand Clinical Research, Christchurch, New Zealand"],"raw_author_name":"Russell S. Scott"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["New Zealand Clinical Research, Christchurch, New Zealand"],"raw_author_name":"Jane Kerr"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Montreal Heart Institute, Universit\u00e9 de Montr\u00e9al, Montreal"],"raw_author_name":"Jean-Claude Tardif"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["University College London Hospitals NHS Foundation Trust, London"],"raw_author_name":"Catherine Lunken"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Institute of Cardiovascular Science, University College London, London"],"raw_author_name":"Steve E. Humphries"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Verve Therapeutics, a wholly owned subsidiary of Eli Lilly, Boston"],"raw_author_name":"Verena Karsten"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Verve Therapeutics, a wholly owned subsidiary of Eli Lilly, Boston"],"raw_author_name":"Patrick D. Tyler"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Verve Therapeutics, a wholly owned subsidiary of Eli Lilly, Boston"],"raw_author_name":"Xinyan Zhang"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Verve Therapeutics, a wholly owned subsidiary of Eli Lilly, Boston"],"raw_author_name":"Nidal Huniti"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Verve Therapeutics, a wholly owned subsidiary of Eli Lilly, Boston"],"raw_author_name":"Patrick A. Flight"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Verve Therapeutics, a wholly owned subsidiary of Eli Lilly, Boston"],"raw_author_name":"Chelsey L. Jensen"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Verve Therapeutics, a wholly owned subsidiary of Eli Lilly, Boston"],"raw_author_name":"Rick Falzone"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Verve Therapeutics, a wholly owned subsidiary of Eli Lilly, Boston"],"raw_author_name":"Joseph C. Biedenkapp"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Verve Therapeutics, a wholly owned subsidiary of Eli Lilly, Boston"],"raw_author_name":"Troy Lister"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Verve Therapeutics, a wholly owned subsidiary of Eli Lilly, Boston"],"raw_author_name":"Leslie E. Stolz"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Verve Therapeutics, a wholly owned subsidiary of Eli Lilly, Boston"],"raw_author_name":"Amit V. Khera"},{"author_position":"last","is_corresponding":false,"raw_affiliation_strings":["Verve Therapeutics, a wholly owned subsidiary of Eli Lilly, Boston"],"raw_author_name":"Sekar Kathiresan"}]}