{"best_oa_location":{"endpoint_id":null,"evidence":"deprecated","host_type":"repository","is_best":true,"license":"cc-by-nd","oa_date":"2026-10-28","pmh_id":null,"repository_institution":"Cold Spring Harbor Laboratory","updated":"deprecated","url":"https://doi.org/10.1101/2023.12.15.571696","url_for_landing_page":"https://doi.org/10.1101/2023.12.15.571696","url_for_pdf":null,"version":"acceptedVersion"},"data_standard":2,"doi":"10.1038/s41588-026-02786-6","doi_url":"https://doi.org/10.1038/s41588-026-02786-6","first_oa_location":{"endpoint_id":null,"evidence":"deprecated","host_type":"repository","is_best":true,"license":"cc-by-nd","oa_date":"2026-10-28","pmh_id":null,"repository_institution":"Cold Spring Harbor Laboratory","updated":"deprecated","url":"https://doi.org/10.1101/2023.12.15.571696","url_for_landing_page":"https://doi.org/10.1101/2023.12.15.571696","url_for_pdf":null,"version":"acceptedVersion"},"genre":"journal-article","has_repository_copy":true,"is_oa":true,"is_paratext":false,"journal_is_in_doaj":false,"journal_is_oa":false,"journal_issn_l":"1061-4036","journal_issns":"1061-4036,1546-1718","journal_name":"Nature Genetics","oa_locations":[{"endpoint_id":null,"evidence":"deprecated","host_type":"repository","is_best":true,"license":"cc-by-nd","oa_date":"2026-10-28","pmh_id":null,"repository_institution":"Cold Spring Harbor Laboratory","updated":"deprecated","url":"https://doi.org/10.1101/2023.12.15.571696","url_for_landing_page":"https://doi.org/10.1101/2023.12.15.571696","url_for_pdf":null,"version":"acceptedVersion"},{"endpoint_id":"ac9de7698155b820de7","evidence":"deprecated","host_type":"repository","is_best":false,"license":"cc-by-nd","oa_date":"2026-10-28","pmh_id":"oai:pubmedcentral.nih.gov:10760134","repository_institution":"National Institutes of Health","updated":"deprecated","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10760134","url_for_landing_page":"https://www.ncbi.nlm.nih.gov/pmc/articles/10760134","url_for_pdf":null,"version":"submittedVersion"},{"endpoint_id":null,"evidence":"deprecated","host_type":"repository","is_best":false,"license":"cc-by","oa_date":"2026-10-28","pmh_id":null,"repository_institution":"European Organization for Nuclear Research","updated":"deprecated","url":"https://doi.org/10.5281/zenodo.10084013","url_for_landing_page":"https://doi.org/10.5281/zenodo.10084013","url_for_pdf":null,"version":null},{"endpoint_id":null,"evidence":"deprecated","host_type":"repository","is_best":false,"license":"cc-by","oa_date":"2026-10-28","pmh_id":null,"repository_institution":"European Organization for Nuclear Research","updated":"deprecated","url":"https://doi.org/10.5281/zenodo.10084014","url_for_landing_page":"https://doi.org/10.5281/zenodo.10084014","url_for_pdf":null,"version":null},{"endpoint_id":null,"evidence":"deprecated","host_type":"repository","is_best":false,"license":"cc-by","oa_date":"2026-10-28","pmh_id":null,"repository_institution":"European Organization for Nuclear Research","updated":"deprecated","url":"https://doi.org/10.5281/zenodo.10138353","url_for_landing_page":"https://doi.org/10.5281/zenodo.10138353","url_for_pdf":null,"version":null},{"endpoint_id":null,"evidence":"deprecated","host_type":"repository","is_best":false,"license":"cc-by","oa_date":"2026-10-28","pmh_id":null,"repository_institution":"European Organization for Nuclear Research","updated":"deprecated","url":"https://doi.org/10.5281/zenodo.10140514","url_for_landing_page":"https://doi.org/10.5281/zenodo.10140514","url_for_pdf":null,"version":null},{"endpoint_id":null,"evidence":"deprecated","host_type":"repository","is_best":false,"license":"cc-by","oa_date":"2026-10-28","pmh_id":null,"repository_institution":"European Organization for Nuclear Research","updated":"deprecated","url":"https://doi.org/10.5281/zenodo.13754822","url_for_landing_page":"https://doi.org/10.5281/zenodo.13754822","url_for_pdf":null,"version":null},{"endpoint_id":null,"evidence":"deprecated","host_type":"repository","is_best":false,"license":"cc-by","oa_date":"2026-10-28","pmh_id":null,"repository_institution":"European Organization for Nuclear Research","updated":"deprecated","url":"https://doi.org/10.5281/zenodo.16573423","url_for_landing_page":"https://doi.org/10.5281/zenodo.16573423","url_for_pdf":null,"version":null},{"endpoint_id":null,"evidence":"deprecated","host_type":"repository","is_best":false,"license":"cc-by","oa_date":"2026-10-28","pmh_id":null,"repository_institution":"European Organization for Nuclear Research","updated":"deprecated","url":"https://doi.org/10.5281/zenodo.19670721","url_for_landing_page":"https://doi.org/10.5281/zenodo.19670721","url_for_pdf":null,"version":null}],"oa_locations_embargoed":[],"oa_status":"green","published_date":"2026-10-28","publisher":"Springer Science and Business Media LLC","title":"Population-scale single-nucleus multi-omic profiling of skeletal muscle reveals extensive context-specific genetic regulation","updated":"2026-11-04T11:18:25Z","year":2026,"z_authors":[{"author_position":"first","is_corresponding":false,"raw_affiliation_strings":["Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA","University of Michigan\u2013Ann Arbor"],"raw_author_name":"Arushi Varshney"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA"],"raw_author_name":"Nandini Manickam"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA"],"raw_author_name":"Peter Orchard"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA"],"raw_author_name":"Adelaide Tovar"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA","Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA"],"raw_author_name":"Christa Ventresca"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA"],"raw_author_name":"Zhenhao Zhang"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA"],"raw_author_name":"Fan Feng"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA"],"raw_author_name":"Joseph Mears"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_author_name":"Michael R. Erdos"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_author_name":"Narisu Narisu"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA"],"raw_author_name":"Kirsten Nishino"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA"],"raw_author_name":"Vivek Rai"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA"],"raw_author_name":"Heather M. Stringham"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA"],"raw_author_name":"Anne U. Jackson"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Biomedical Research Core Facilities Advanced Genomics Core, University of Michigan, Ann Arbor, MI, USA"],"raw_author_name":"Tricia Tamsen"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA"],"raw_author_name":"Chao Gao"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Health, Detroit, MI, USA"],"raw_author_name":"Mao Yang"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Biomedical Research Core Facilities Advanced Genomics Core, University of Michigan, Ann Arbor, MI, USA"],"raw_author_name":"Olivia I. Koues"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA"],"raw_author_name":"Joshua D. Welch"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA"],"raw_author_name":"Charles F. Burant"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Health, Detroit, MI, USA"],"raw_author_name":"L. Keoki Williams"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["South Texas Diabetes and Obesity Research Institute, School of Medicine, University of Texas, Rio Grande Valley, TX, USA"],"raw_author_name":"Chris Jenkinson"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Department of Medicine/Diabetes, UT Health San Antonio, San Antonio, TX, USA"],"raw_author_name":"Ralph A. DeFronzo"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Department of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX, USA","Department of Cellular and Integrative Physiology, UT Health San Antonio, San Antonio, TX, USA","Department of Medicine/Diabetes, UT Health San Antonio, San Antonio, TX, USA"],"raw_author_name":"Luke Norton"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Wellbeing Services County of South Karelia, South Karelia, Finland"],"raw_author_name":"Jouko Saramies"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland","Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland","Kuopio Research Institute of Exercise Medicine, Kuopio, Finland"],"raw_author_name":"Timo A. Lakka"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland"],"raw_author_name":"Markku Laakso"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland","Department of Public Health, University of Helsinki, Helsinki, Finland","Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia"],"raw_author_name":"Jaakko Tuomilehto"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Department of Genetics, University of North Carolina, Chapel Hill, NC, USA"],"raw_author_name":"Karen L. Mohlke"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA","Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA"],"raw_author_name":"Jacob O. Kitzman"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland","Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland","Minerva Foundation Institute for Medical Research, Helsinki, Finland","University of Helsinki, Faculty of Medicine, Research Programs Unit, Clinical and Molecular Metabolism (CAMM), Helsinki, Finland"],"raw_author_name":"Heikki A. Koistinen"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA"],"raw_author_name":"Jie Liu"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA"],"raw_author_name":"Michael Boehnke"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_author_name":"Francis S. Collins"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA"],"raw_author_name":"Laura J. Scott"},{"author_position":"last","is_corresponding":true,"raw_affiliation_strings":["Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. scjp@umich.edu","Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA. scjp@umich.edu","Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. scjp@umich.edu"],"raw_author_name":"Stephen C. J. Parker"}]}