{"best_oa_location":{"endpoint_id":null,"evidence":"deprecated","host_type":"publisher","is_best":true,"license":"cc-by-nc-nd","oa_date":"2026-03-04","pmh_id":null,"repository_institution":null,"updated":"deprecated","url":"https://doi.org/10.1038/s41586-026-10176-5","url_for_landing_page":"https://doi.org/10.1038/s41586-026-10176-5","url_for_pdf":null,"version":"publishedVersion"},"data_standard":2,"doi":"10.1038/s41586-026-10176-5","doi_url":"https://doi.org/10.1038/s41586-026-10176-5","first_oa_location":{"endpoint_id":null,"evidence":"deprecated","host_type":"publisher","is_best":true,"license":"cc-by-nc-nd","oa_date":"2026-03-04","pmh_id":null,"repository_institution":null,"updated":"deprecated","url":"https://doi.org/10.1038/s41586-026-10176-5","url_for_landing_page":"https://doi.org/10.1038/s41586-026-10176-5","url_for_pdf":null,"version":"publishedVersion"},"genre":"journal-article","has_repository_copy":true,"is_oa":true,"is_paratext":false,"journal_is_in_doaj":false,"journal_is_oa":false,"journal_issn_l":"0028-0836","journal_issns":"0028-0836,1476-4687","journal_name":"Nature","oa_locations":[{"endpoint_id":null,"evidence":"deprecated","host_type":"publisher","is_best":true,"license":"cc-by-nc-nd","oa_date":"2026-03-04","pmh_id":null,"repository_institution":null,"updated":"deprecated","url":"https://doi.org/10.1038/s41586-026-10176-5","url_for_landing_page":"https://doi.org/10.1038/s41586-026-10176-5","url_for_pdf":null,"version":"publishedVersion"},{"endpoint_id":"ac9de7698155b820de7","evidence":"deprecated","host_type":"repository","is_best":false,"license":"cc-by-nc-nd","oa_date":"2026-03-04","pmh_id":"oai:pubmedcentral.nih.gov:13128491","repository_institution":"National Institutes of Health","updated":"deprecated","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13128491/","url_for_landing_page":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13128491/","url_for_pdf":null,"version":"submittedVersion"}],"oa_locations_embargoed":[],"oa_status":"hybrid","published_date":"2026-03-04","publisher":"Springer Science and Business Media LLC","title":"Genome modelling and design across all domains of life with Evo 2","updated":"2026-05-04T08:56:22Z","year":2026,"z_authors":[{"author_position":"first","is_corresponding":true,"raw_affiliation_strings":["Arc Institute, Palo Alto, CA, USA","Evo 2 Core Team, Palo Alto, CA, USA","Stanford University, Stanford, CA, USA"],"raw_author_name":"Garyk Brixi"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Arc Institute, Palo Alto, CA, USA","Evo 2 Core Team, Palo Alto, CA, USA"],"raw_author_name":"Matthew G. Durrant"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Arc Institute, Palo Alto, CA, USA","Evo 2 Core Team, Palo Alto, CA, USA"],"raw_author_name":"Jerome Ku"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Arc Institute, Palo Alto, CA, USA","Evo 2 Core Team, Palo Alto, CA, USA","University of California, Berkeley, Berkeley, CA, USA"],"raw_author_name":"Mohsen Naghipourfar"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Evo 2 Core Team, Palo Alto, CA, USA","Liquid AI, San Francisco, CA, USA","Stanford University, Stanford, CA, USA"],"raw_author_name":"Michael Poli"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Arc Institute, Palo Alto, CA, USA","Evo 2 Core Team, Palo Alto, CA, USA"],"raw_author_name":"Gwanggyu Sun"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Evo 2 Core Team, Palo Alto, CA, USA","Independent Researcher, San Francisco, CA, USA","OpenAI, San Francisco, CA, USA"],"raw_author_name":"Greg Brockman"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Arc Institute, Palo Alto, CA, USA","Evo 2 Core Team, Palo Alto, CA, USA","Stanford University, Stanford, CA, USA"],"raw_author_name":"Daniel Chang"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Arc Institute, Palo Alto, CA, USA","Evo 2 Core Team, Palo Alto, CA, USA"],"raw_author_name":"Alison Fanton"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Arc Institute, Palo Alto, CA, USA","Evo 2 Core Team, Palo Alto, CA, USA"],"raw_author_name":"Gabriel A. Gonzalez"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Arc Institute, Palo Alto, CA, USA","Evo 2 Core Team, Palo Alto, CA, USA","Stanford University, Stanford, CA, USA"],"raw_author_name":"Samuel H. King"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Arc Institute, Palo Alto, CA, USA","Evo 2 Core Team, Palo Alto, CA, USA","Stanford University, Stanford, CA, USA"],"raw_author_name":"David B. Li"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Arc Institute, Palo Alto, CA, USA","Evo 2 Core Team, Palo Alto, CA, USA","Stanford University, Stanford, CA, USA"],"raw_author_name":"Aditi T. Merchant"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Evo 2 Core Team, Palo Alto, CA, USA","Stanford University, Stanford, CA, USA"],"raw_author_name":"Eric Nguyen"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Arc Institute, Palo Alto, CA, USA","Evo 2 Core Team, Palo Alto, CA, USA"],"raw_author_name":"Chiara Ricci-Tam"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Evo 2 Core Team, Palo Alto, CA, USA","NVIDIA, Santa Clara, CA, USA"],"raw_author_name":"David W. Romero"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Arc Institute, Palo Alto, CA, USA","Evo 2 Core Team, Palo Alto, CA, USA"],"raw_author_name":"Jonathan C. Schmok"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Evo 2 Core Team, Palo Alto, CA, USA","NVIDIA, Santa Clara, CA, USA"],"raw_author_name":"Ali Taghibakhshi"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Evo 2 Core Team, Palo Alto, CA, USA","NVIDIA, Santa Clara, CA, USA"],"raw_author_name":"Anton Vorontsov"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Evo 2 Core Team, Palo Alto, CA, USA","Independent Researcher, San Francisco, CA, USA"],"raw_author_name":"Brandon Yang"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Goodfire, San Francisco, CA, USA"],"raw_author_name":"Myra Deng"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Goodfire, San Francisco, CA, USA"],"raw_author_name":"Liv Gorton"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Goodfire, San Francisco, CA, USA"],"raw_author_name":"Nam Nguyen"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Goodfire, San Francisco, CA, USA"],"raw_author_name":"Nicholas K. Wang"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Goodfire, San Francisco, CA, USA"],"raw_author_name":"Michael T. Pearce"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Goodfire, San Francisco, CA, USA"],"raw_author_name":"Elana Simon"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Columbia University, New York, NY, USA"],"raw_author_name":"Etowah Adams"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["University of Washington, Seattle, WA, USA"],"raw_author_name":"Zachary J. Amador"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Stanford University, Stanford, CA, USA"],"raw_author_name":"Euan A. Ashley"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Stanford University, Stanford, CA, USA"],"raw_author_name":"Stephen A. Baccus"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Stanford University, Stanford, CA, USA"],"raw_author_name":"Haoyu Dai"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Stanford University, Stanford, CA, USA"],"raw_author_name":"Steven Dillmann"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Stanford University, Stanford, CA, USA"],"raw_author_name":"Stefano Ermon"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Arc Institute, Palo Alto, CA, USA","Stanford University, Stanford, CA, USA"],"raw_author_name":"Daniel Guo"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Arc Institute, Palo Alto, CA, USA","University of California, Berkeley, Berkeley, CA, USA"],"raw_author_name":"Michael H. Herschl"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Arc Institute, Palo Alto, CA, USA"],"raw_author_name":"Rajesh Ilango"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["NVIDIA, Santa Clara, CA, USA"],"raw_author_name":"Ken Janik"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["University of California, Berkeley, Berkeley, CA, USA"],"raw_author_name":"Amy X. Lu"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Arc Institute, Palo Alto, CA, USA"],"raw_author_name":"Reshma Mehta"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["University of California, Berkeley, Berkeley, CA, USA"],"raw_author_name":"Mohammad R. K. Mofrad"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Stanford University, Stanford, CA, USA"],"raw_author_name":"Madelena Y. Ng"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Johns Hopkins University, Baltimore, MD, USA"],"raw_author_name":"Jaspreet Pannu"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Stanford University, Stanford, CA, USA"],"raw_author_name":"Christopher R\u00e9"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["NVIDIA, Santa Clara, CA, USA"],"raw_author_name":"John St. John"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Arc Institute, Palo Alto, CA, USA"],"raw_author_name":"Jeremy Sullivan"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Arc Institute, Palo Alto, CA, USA","Stanford University, Stanford, CA, USA"],"raw_author_name":"Joseph Tey"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Stanford University, Stanford, CA, USA"],"raw_author_name":"Ben Viggiano"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["University of California, Berkeley, Berkeley, CA, USA"],"raw_author_name":"Kevin Zhu"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["NVIDIA, Santa Clara, CA, USA"],"raw_author_name":"Greg Zynda"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Goodfire, San Francisco, CA, USA"],"raw_author_name":"Daniel Balsam"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Arc Institute, Palo Alto, CA, USA"],"raw_author_name":"Patrick Collison"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["NVIDIA, Santa Clara, CA, USA"],"raw_author_name":"Anthony B. Costa"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Stanford University, Stanford, CA, USA"],"raw_author_name":"Tina Hernandez-Boussard"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Goodfire, San Francisco, CA, USA"],"raw_author_name":"Eric Ho"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["NVIDIA, Santa Clara, CA, USA"],"raw_author_name":"Ming-Yu Liu"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Goodfire, San Francisco, CA, USA"],"raw_author_name":"Thomas McGrath"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["NVIDIA, Santa Clara, CA, USA"],"raw_author_name":"Kimberly Powell"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Evo 2 Core Team, Palo Alto, CA, USA","University of Washington, Seattle, WA, USA"],"raw_author_name":"Sudarshan Pinglay"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Arc Institute, Palo Alto, CA, USA","Evo 2 Core Team, Palo Alto, CA, USA"],"raw_author_name":"Dave P. Burke"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Arc Institute, Palo Alto, CA, USA","Evo 2 Core Team, Palo Alto, CA, USA","University of California, San Francisco, San Francisco, CA, USA"],"raw_author_name":"Hani Goodarzi"},{"author_position":"middle","is_corresponding":false,"raw_affiliation_strings":["Arc Institute, Palo Alto, CA, USA. patrick@arcinstitute.org","Evo 2 Core Team, Palo Alto, CA, USA. patrick@arcinstitute.org","University of California, Berkeley, Berkeley, CA, USA. patrick@arcinstitute.org"],"raw_author_name":"Patrick D. Hsu"},{"author_position":"last","is_corresponding":false,"raw_affiliation_strings":["Arc Institute, Palo Alto, CA, USA. brianhie@stanford.edu","Evo 2 Core Team, Palo Alto, CA, USA. brianhie@stanford.edu","Stanford University, Stanford, CA, USA. brianhie@stanford.edu"],"raw_author_name":"Brian L. Hie"}]}